I just bought a 2012 Silverado. Truck is in great shape, only issues I’m having is that the front speaker cuts in and out sometimes and the rear driver side window and front passenger window will roll down, but not up every time. The windows do roll up randomly so I just have to try the switch over and over until it works. Is this a fuse or wiring issue that is affecting all three things?

 

Most likely the speaker is blown and needs replaced. Check if you have the BOSE system or not because the speakers are different.
also, sounds like the window switch pack needs changed. See if the windows roll up with the switch dedicated to that window only…