I have had no problems with driver door...I exited truck after I started it up, got out to clear snow...I left the door open..cleared off windshield....Got in, shut door and now I cannot open from either interior/exterior handle.
The lock works...all electrical works fine....
Is it possible to get the panel off if I can't open the door?

 

yes, but the panel will probably be damaged. not much else you can do at this point. post a pic of the door panel and i will tell you where the screws are.

 

You mentioned snow, but didn't say how cold it was. Some door latches will freeze up in cold weather, especially if there has been rain or you've just washed the car. Perhaps if you could park it in a warm garage for awhile, or warm the door latch area with a hair dryer or heat gun it might thaw out. Good luck!