So here is one for you, I have been working on our 06 express van with misfire code p0300 random misfire. I have read many threads and have tried many things and it still sets code. When hooked up to scan tool in the misfire data of mode 6, I can sit and watch each cyl. as they occationally misfire. Misfire history shows each cyl has over 4500 misfires logged, I have removed and replaced plugs and wires only because it has 100k on it and doesnt hurt to do now. I know the COP's are good and the fuel is good. I have a spare complete engine sitting in the shop, so I took the maf sensor from it and replaced it. Still sets code. This engine runs, but is rough at idle only for a second or two when the misfire happens(kinda like the engine skips ever so often). Intake vacuum is 11-14psi, I am suspecting a possible intake gasket, but not sure, only because I know they are common. Anyone have any other things they might check? I dont have plugged cats either...

 

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